glp-1 next generation Revolutionizing obesity treatment: The emerging role of receptor agonists and next-generation pharmacotherapies The next generation of GLP-1

21,23 Managing other preexisting GI conditions, such as gastroesophageal reflux disease or constipation, before initiating GLP-1 RAs can reduce the likelihood of severe GI AEs and improve overall tolerability

Previous weight loss history Your track record matters

What is most disturbing is the rise in children under the age of 5 who are now overweight or living with obesity

Discordance between randomised controlled trials and observational studies

This perspective contrasts with failed targets , for which rigorous clinical evaluation has demonstrated unacceptable on-target toxicity or lack of efficacy at therapeutically relevant exposures

Challenges and management of liver cirrhosis: Practical issues in the therapy of patients with cirrhosis due to NAFLD and NASH